Searching for a Putative Mechanism of RIZ2 Tumor-Promoting Function in Cancer Models

Searching for a Putative Mechanism of RIZ2 Tumor-Promoting Function in Cancer Models

Positive Regulatory Domain (PRDM) gene family members commonly express two main molecular variants, the PR-plus isoform usually acting as tumor suppressor and the PR-minus one functioning as oncogene. Accordingly, PRDM2/RIZ encodes for RIZ1 (PR-plus) and RIZ2 (PR-minus). In human cancers, genetic or...

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Bibliographic Details
Main Authors: Monica Rienzo, Anna Sorrentino, Erika Di Zazzo, Marzia Di Donato, Vincenzo Carafa, Maria Michela Marino, Caterina De Rosa, Patrizia Gazzerro, Gabriella Castoria, Lucia Altucci, Amelia Casamassimi, Ciro Abbondanza
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Oncology
Subjects:
PRDM2
RIZ2 overexpression
microarray
cell proliferation
apoptosis
3D models
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.583533/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.583533/full

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