Peripheral decarboxylase inhibitors paradoxically induce aromatic L-amino acid decarboxylase
Abstract Peripheral decarboxylase inhibitors (PDIs) prevent conversion of levodopa to dopamine in the blood by the enzyme aromatic L-amino acid decarboxylase (AADC). Alterations in enzyme activity may contribute to the required higher dosages of levodopa observed in many patients with Parkinson’s di...
Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-03-01
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Series: | npj Parkinson's Disease |
Online Access: | https://doi.org/10.1038/s41531-021-00172-z |