Pharmacokinetics and Metabolite Profiling of Trepibutone in Rats Using Ultra-High Performance Liquid Chromatography Combined With Hybrid Quadrupole-Orbitrap and Triple Quadrupole Mass Spectrometers

Pharmacokinetics and Metabolite Profiling of Trepibutone in Rats Using Ultra-High Performance Liquid Chromatography Combined With Hybrid Quadrupole-Orbitrap and Triple Quadrupole Mass Spectrometers

Trepibutone was widely used for cholelithiasis, cholecystitis, biliary tract dyskinesia, cholecystectomy syndrome, and chronic pancreatitis in clinic. However, few investigations on trepibutone have been conducted. In this study, an accurate, sensitive, and selective analytical method was developed...

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Bibliographic Details
Main Authors: Zhi Sun, Jie Yang, Liwei Liu, Yanyan Xu, Lin Zhou, Qingquan Jia, Yingying Shi, Xiangyu Du, Jian Kang, Lihua Zuo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Pharmacology
Subjects:
trepibutone
pharmacokinetics
metabolite profiling
UHPLC-MS/MS
UHPLC-Q-orbitrap HRMS
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01266/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01266/full

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