Rapid and reliable healing of critical size bone defects with genetically modified sheep muscle

Rapid and reliable healing of critical size bone defects with genetically modified sheep muscle

Large segmental defects in bone fail to heal and remain a clinical problem. Muscle is highly osteogenic, and preliminary data suggest that autologous muscle tissue expressing bone morphogenetic protein-2 (BMP-2) efficiently heals critical size defects in rats. Translation into possible human clinica...

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Bibliographic Details
Main Authors: F Liu, E Ferreira, RM Porter, V Glatt, M Schinhan, Z Shen, MA Randolph, CA Kirker-Head, C Wehling, MS Vrahas, CH Evans, JW Wells
Format: Article
Language:English
Published: AO Research Institute Davos 2015-09-01
Series:European Cells & Materials
Subjects:
Bone healing
gene therapy
muscle
adenovirus
bone morphogenetic protein
sheep
rat
immunosuppression
Online Access:http://www.ecmjournal.org/papers/vol030/pdf/v030a09.pdf

Internet

http://www.ecmjournal.org/papers/vol030/pdf/v030a09.pdf

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