Investigating the effects of additional truncating variants in DNA-repair genes on breast cancer risk in BRCA1-positive women

Investigating the effects of additional truncating variants in DNA-repair genes on breast cancer risk in BRCA1-positive women

Abstract Background Inherited pathogenic variants in BRCA1 and BRCA2 are the most common causes of hereditary breast and ovarian cancer (HBOC). The risk of developing breast cancer by age 80 in women carrying a BRCA1 pathogenic variant is 72%. The lifetime risk varies between families and even withi...

Full description

Bibliographic Details
Main Authors: Ilnaz Sepahi, Ulrike Faust, Marc Sturm, Kristin Bosse, Martin Kehrer, Tilman Heinrich, Kathrin Grundman-Hauser, Peter Bauer, Stephan Ossowski, Hana Susak, Raymonda Varon, Evelin Schröck, Dieter Niederacher, Bernd Auber, Christian Sutter, Norbert Arnold, Eric Hahnen, Bernd Dworniczak, Shan Wang-Gorke, Andrea Gehrig, Bernhard H. F. Weber, Christoph Engel, Johannes R. Lemke, Andreas Hartkopf, Huu Phuc Nguyen, Olaf Riess, Christopher Schroeder
Format: Article
Language:English
Published: BMC 2019-08-01
Series:BMC Cancer
Subjects:
Breast cancer
Age at onset
DNA-repair genes
Next-generation-sequencing
Panel sequencing
Extreme phenotypes
Online Access:http://link.springer.com/article/10.1186/s12885-019-5946-0

Internet

http://link.springer.com/article/10.1186/s12885-019-5946-0

Similar Items