ATP-Dependent Persister Formation in Escherichia coli

Persisters are dormant variants that form a subpopulation of cells tolerant to antibiotics. Persisters are largely responsible for the recalcitrance of chronic infections to therapy. In Escherichia coli, one widely accepted model of persister formation holds that stochastic accumulation of ppGpp cau...

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Bibliographic Details
Main Authors: Yue Shan, Autumn Brown Gandt, Sarah E. Rowe, Julia P. Deisinger, Brian P. Conlon, Kim Lewis, Karen Bush
Format: Article
Language:English
Published: American Society for Microbiology 2017-02-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/8/1/e02267-16