A comparison of the statistical performance of different meta-analysis models for the synthesis of subgroup effects from randomized clinical trials

A comparison of the statistical performance of different meta-analysis models for the synthesis of subgroup effects from randomized clinical trials

Abstract Background When investigating subgroup effects in meta-analysis, it is unclear whether accounting in meta-regression for between-trial variation in treatment effects, but not between-trial variation in treatment interaction effects when such effects are present, leads to biased estimates, c...

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Bibliographic Details
Main Authors: Bruno R. da Costa, Alex J. Sutton
Format: Article
Language:English
Published: BMC 2019-10-01
Series:BMC Medical Research Methodology
Subjects:
Individual patient data
Meta-analysis
Random-effects
Evidence synthesis
Interaction effects
Subgroup analysis
Online Access:http://link.springer.com/article/10.1186/s12874-019-0831-8

Internet

http://link.springer.com/article/10.1186/s12874-019-0831-8

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