NGS Evaluation of Colorectal Cancer Reveals Interferon Gamma Dependent Expression of Immune Checkpoint Genes and Identification of Novel IFNγ Induced Genes

NGS Evaluation of Colorectal Cancer Reveals Interferon Gamma Dependent Expression of Immune Checkpoint Genes and Identification of Novel IFNγ Induced Genes

To evaluate the expression of immune checkpoint genes, their concordance with expression of IFNγ, and to identify potential novel ICP related genes (ICPRG) in colorectal cancer (CRC), the biological connectivity of six well documented (“classical”) ICPs (CTLA4, PD1, PDL1, Tim3, IDO1, and LAG3) with...

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Bibliographic Details
Main Authors: Lai Xu, Lorraine Pelosof, Rong Wang, Hugh I. McFarland, Wells W. Wu, Je-Nie Phue, Chun-Ting Lee, Rong-Fong Shen, Hartmut Juhl, Lei-Hong Wu, Wei-Lun Alterovitz, Emanuel Petricon, Amy S. Rosenberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
colorectal cancer
IFNγ gradient
immune checkpoint genes
co-expression network
novel immune checkpoint related genes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00224/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.00224/full

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