The Vacuolar H<sup>+</sup> ATPase α3 Subunit Negatively Regulates Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cells

The Vacuolar H<sup>+</sup> ATPase α3 Subunit Negatively Regulates Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cells

Increased metabolic acid production and upregulation of net acid extrusion render pH homeostasis profoundly dysregulated in many cancers. Plasma membrane activity of vacuolar H<sup>+</sup> ATPases (V-ATPases) has been implicated in acid extrusion and invasiveness of some cancers, yet oft...

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Bibliographic Details
Main Authors: Mette Flinck, Sofie Hagelund, Andrej Gorbatenko, Marc Severin, Elena Pedraz-Cuesta, Ivana Novak, Christian Stock, Stine Falsig Pedersen
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cells
Subjects:
pdac
tcirg1
atp6v0a3
invasion
migration
matrix degradation
proliferation
ph-regulation
autophagy
Online Access:https://www.mdpi.com/2073-4409/9/2/465

Internet

https://www.mdpi.com/2073-4409/9/2/465

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