Thematic Review Series: Lipid Posttranslational Modifications. Prelamin A, Zmpste24, misshapen cell nuclei, and progeria—new evidence suggesting that protein farnesylation could be important for disease pathogenesis

Thematic Review Series: Lipid Posttranslational Modifications. Prelamin A, Zmpste24, misshapen cell nuclei, and progeria—new evidence suggesting that protein farnesylation could be important for disease pathogenesis

Prelamin A undergoes multistep processing to yield lamin A, a structural protein of the nuclear lamina. Prelamin A terminates with a CAAX motif, which triggers farnesylation of a C-terminal cysteine (the C of the CAAX motif), endoproteolytic release of the last three amino acids (the AAX), and methy...

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Bibliographic Details
Main Authors: Stephen G. Young, Loren G. Fong, Susan Michaelis
Format: Article
Language:English
Published: Elsevier 2005-12-01
Series:Journal of Lipid Research
Subjects:
protein prenylation
laminopathy
aging
Ste24
a-factor
lamin A/C
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752032842X

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http://www.sciencedirect.com/science/article/pii/S002222752032842X

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