A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development.

A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development.

The separation of the optic neuroepithelium into future retina and retinal pigment epithelium (RPE) is a critical event in early eye development in vertebrates. Here we show in mice that the transcription factor PAX6, well-known for its retina-promoting activity, also plays a crucial role in early p...

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Bibliographic Details
Main Authors: Kapil Bharti, Melanie Gasper, Jingxing Ou, Martha Brucato, Katharina Clore-Gronenborn, James Pickel, Heinz Arnheiter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3390378?pdf=render

Internet

http://europepmc.org/articles/PMC3390378?pdf=render

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