Misplaced NMDA receptors in epileptogenesis contribute to excitotoxicity

Misplaced NMDA receptors in epileptogenesis contribute to excitotoxicity

Pharmacological blockade of NR2B-containing N-methyl-d-aspartate receptors (NMDARs) during epileptogenesis reduces neurodegeneration provoked in the rodent hippocampus by status epilepticus. The functional consequences of NMDAR activation are crucially influenced by their synaptic vs extrasynaptic l...

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Bibliographic Details
Main Authors: Angelisa Frasca, Marlien Aalbers, Federica Frigerio, Fabio Fiordaliso, Monica Salio, Marco Gobbi, Alfredo Cagnotto, Fabrizio Gardoni, Giorgio S. Battaglia, Govert Hoogland, Monica Di Luca, Annamaria Vezzani
Format: Article
Language:English
Published: Elsevier 2011-08-01
Series:Neurobiology of Disease
Subjects:
Astroglia
Epilepsy
Glutamate receptor
Seizure
Neuroprotective agents
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111001410

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http://www.sciencedirect.com/science/article/pii/S0969996111001410

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