Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer

Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer

Abstract Background Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy characterized by tumor heterogeneity, locoregional metastases, and resistance to existing treatments. Although a number of genomic and molecular alterations associated with HNSCC have been identified, they...

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Bibliographic Details
Main Authors: Vinay K. Kartha, Khalid A. Alamoud, Khikmet Sadykov, Bach-Cuc Nguyen, Fabrice Laroche, Hui Feng, Jina Lee, Sara I. Pai, Xaralabos Varelas, Ann Marie Egloff, Jennifer E. Snyder-Cappione, Anna C. Belkina, Manish V. Bais, Stefano Monti, Maria A. Kukuruzinska
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Genome Medicine
Subjects:
HNSCC
β-Catenin/CBP transcriptional activity
Aggressive tumor cells
ICG-001
TCGA
Online Access:http://link.springer.com/article/10.1186/s13073-018-0569-7

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http://link.springer.com/article/10.1186/s13073-018-0569-7

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