Formulation and evaluation of a bioadhesive patch for buccal delivery of tizanidine

Formulation and evaluation of a bioadhesive patch for buccal delivery of tizanidine

Tizanidine hydrochloride (THCl) is an antispasmodic agent which undergoes extensive first pass metabolism making it a possible candidate for buccal delivery. The aim of this study was to prepare a monolayered buccal patch containing THCl using the emulsification solvent evaporation method. Fourteen...

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Bibliographic Details
Main Authors: Mohamed S. Pendekal, Pramod K. Tegginamat
Format: Article
Language:English
Published: Elsevier 2012-06-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Tizanidine hydrochloride
Buccal patch
Chitosan
Eudragit® RS 100
Eudragit® RL 100
In vitro drug release
In vitro mucoadhesion
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383512000287

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http://www.sciencedirect.com/science/article/pii/S2211383512000287

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