DNA methylation of SPARC and chronic low back pain

DNA methylation of SPARC and chronic low back pain

<p>Abstract</p> <p>Background</p> <p>The extracellular matrix protein SPARC (Secreted Protein, Acidic, Rich in Cysteine) has been linked to degeneration of the intervertebral discs and chronic low back pain (LBP). In humans, SPARC protein expression is decreased as a fu...

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Bibliographic Details
Main Authors: Dashwood Thomas, Millecamps Magali, Alvarado Sebastian, Tajerian Maral, Anderson Kathleen M, Haglund Lisbet, Ouellet Jean, Szyf Moshe, Stone Laura S
Format: Article
Language:English
Published: SAGE Publishing 2011-08-01
Series:Molecular Pain
Subjects:
SPARC
back pain
DNA methylation
epigenetics
intervertebral disc
aging
gene expression
disc degeneration
Online Access:http://www.molecularpain.com/content/7/1/65

Internet

http://www.molecularpain.com/content/7/1/65

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