Dephosphorylated Polymerase I and Transcript Release Factor Prevents Allergic Asthma Exacerbations by Limiting IL-33 Release

Dephosphorylated Polymerase I and Transcript Release Factor Prevents Allergic Asthma Exacerbations by Limiting IL-33 Release

BackgroundAsthma is a chronic inflammatory disease characterized by airway inflammation and airway hyperresponsiveness (AHR). IL-33 is considered as one of the most critical molecules in asthma pathogenesis. IL-33 is stored in nucleus and passively released during necrosis. But little is known about...

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Bibliographic Details
Main Authors: Yingmeng Ni, Jimin Hao, Xiaoxia Hou, Wei Du, Youchao Yu, Tiantian Chen, Zhuang Wei, Yangyang Li, Fuxiang Zhu, Shuaiwei Wang, Rui Liang, Dan Li, Yue Lu, Kan Liao, Bin Li, Guochao Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
IL33
PTRF
allergic asthma
asthma exacerbation
airway epithelial cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01422/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01422/full

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