Calcium stabilizes the strongest protein fold

Staphylococcal pathogens adhere to their human targets using adhesins, which can withstand extremely high forces. Here, authors use single-molecule force spectroscopy to determine the similarly high unfolding forces of B domains that link the adhesin to the bacterium.

Bibliographic Details
Main Authors: Lukas F. Milles, Eduard M. Unterauer, Thomas Nicolaus, Hermann E. Gaub
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07145-6