Combination of Dichloroacetate and Atorvastatin Regulates Excessive Proliferation and Oxidative Stress in Pulmonary Arterial Hypertension Development via p38 Signaling

Combination of Dichloroacetate and Atorvastatin Regulates Excessive Proliferation and Oxidative Stress in Pulmonary Arterial Hypertension Development via p38 Signaling

Pulmonary arterial hypertension (PAH) is a lethal disease generally characterized by pulmonary artery remodeling. Mitochondrial metabolic disorders have been implicated as a critical regulator of excessively proliferative- and apoptosis-resistant phenotypes in pulmonary artery smooth muscle cells (P...

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Bibliographic Details
Main Authors: Tangzhiming Li, Suqi Li, Yilu Feng, Xiaofang Zeng, Shaohong Dong, Jianghua Li, Lihuang Zha, Hui Luo, Lin Zhao, Bin Liu, Ziwei Ou, Wenchao Lin, Mengqiu Zhang, Sheng Li, Qiuqiong Jiang, Qiangqiang Qi, Qingyao Xu, Zaixin Yu
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2020/6973636

Internet

http://dx.doi.org/10.1155/2020/6973636

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