Methylation-Induced Silencing of ALDH2 Facilitates Lung Adenocarcinoma Bone Metastasis by Activating the MAPK Pathway

Methylation-Induced Silencing of ALDH2 Facilitates Lung Adenocarcinoma Bone Metastasis by Activating the MAPK Pathway

Bone metastasis (BM) dramatically reduces the quality of life and life expectancy in lung adenocarcinoma (LUAD) patients. There is an urgent need to identify potential biomarkers for application in the treatment of this deadly disease. We compared patient BM, LUAD, and para-LUAD tissues using proteo...

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Bibliographic Details
Main Authors: Mengdi Yang, AiTing Wang, Changcan Li, Jing Sun, Gang Yi, Hao Cheng, Xueni Liu, Zhiyu Wang, Yiyi Zhou, Guangyu Yao, Shuai Wang, Rui Liang, Bin Li, Dan Li, Hui Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Oncology
Subjects:
ALDH2
DNA methylation
lung adenocarcinoma
bone metastasis
MAPK
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01141/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.01141/full

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