Genetic breakdown of a Tet-off conditional lethality system for insect population control

Insect population control using conditional lethal systems could break down due to spontaneous mutations that render the system ineffective. Here the authors analyse the structure and frequency of such mutations in Drosophila and suggest the use of dual lethality systems to mitigate their survival.

Bibliographic Details
Main Authors: Yang Zhao, Marc F. Schetelig, Alfred M. Handler
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16807-3