Comparison of a mouse and a novel human scFv-SNAP-auristatin F drug conjugate with potent activity against EGFR-overexpressing human solid tumor cells

Comparison of a mouse and a novel human scFv-SNAP-auristatin F drug conjugate with potent activity against EGFR-overexpressing human solid tumor cells

Mira Woitok,1,2 Diana Klose,1 Stefano Di Fiore,1 Wolfgang Richter,3 Christoph Stein,1 Gerrit Gresch,1 Elena Grieger,1 Stefan Barth,1 Rainer Fischer,1,2 Katharina Kolberg,1,* Judith Niesen1,* 1Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Aachen, Germany; 2Institute of Molecu...

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Bibliographic Details
Main Authors: Woitok M, Klose D, Di Fiore S, Richter W, Stein C, Gresch G, Grieger E, Barth S, Fischer R, Kolberg K, Niesen J
Format: Article
Language:English
Published: Dove Medical Press 2017-07-01
Series:OncoTargets and Therapy
Subjects:
Epidermal growth factor receptor (EGFR)
antibody–drug conjugate (ADC)
SNAP-tag technology
single-chain fragment variable (scFv)
BG-modified auristatin F (AURIF)
monomethyl auristatin analogues (MMAE/MMAF).
Online Access:https://www.dovepress.com/comparison-of-a-mouse-and-a-novel-human-scfv-snap-auristatin-f-drug-co-peer-reviewed-article-OTT

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https://www.dovepress.com/comparison-of-a-mouse-and-a-novel-human-scfv-snap-auristatin-f-drug-co-peer-reviewed-article-OTT

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