Soluble Fas Ligand Is Essential for Blister Formation in Pemphigus

Soluble Fas Ligand Is Essential for Blister Formation in Pemphigus

Pemphigus is a blistering disease characterized by pemphigus autoantibodies (PVIgG) directed mostly against desmogleins (Dsgs), resulting in the loss of keratinocyte adhesion (acantholysis). Yet, the mechanisms underlying blister formation remain to be clarified. We have shown previously that anti-F...

Full description

Bibliographic Details
Main Authors: Roberta Lotti, En Shu, Tiziana Petrachi, Alessandra Marconi, Elisabetta Palazzo, Marika Quadri, Ann Lin, Lorraine A. O’Reilly, Carlo Pincelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
pemphigus
Fas ligand
apoptosis
keratinocytes
autoantibodies
cell adhesion
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00370/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00370/full

Similar Items