TMEM16A in Cystic Fibrosis: Activating or Inhibiting?

TMEM16A in Cystic Fibrosis: Activating or Inhibiting?

The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction. The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is dysfunctional in CF, leading to defects in epithelial...

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Bibliographic Details
Main Authors: Karl Kunzelmann, Jiraporn Ousingsawat, Inês Cabrita, Tereza Doušová, Andrea Bähr, Melanie Janda, Rainer Schreiber, Roberta Benedetto
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Pharmacology
Subjects:
TMEM16A
anoctamin 1
mucus secretion
cystic fibrosis
asthma
COPD
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00003/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00003/full

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