Iron loading is a prominent feature of activated microglia in Alzheimer’s disease patients

Iron loading is a prominent feature of activated microglia in Alzheimer’s disease patients

Abstract Brain iron accumulation has been found to accelerate disease progression in amyloid-β(Aβ) positive Alzheimer patients, though the mechanism is still unknown. Microglia have been identified as key players in the disease pathogenesis, and are highly reactive cells responding to aberrations su...

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Bibliographic Details
Main Authors: Boyd Kenkhuis, Antonios Somarakis, Lorraine de Haan, Oleh Dzyubachyk, Marieke E. IJsselsteijn, Noel F. C. C. de Miranda, Boudewijn P. F. Lelieveldt, Jouke Dijkstra, Willeke M. C. van Roon-Mom, Thomas Höllt, Louise van der Weerd
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer
Microglia
Iron
Ferritin
Human
Online Access:https://doi.org/10.1186/s40478-021-01126-5

Internet

https://doi.org/10.1186/s40478-021-01126-5

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