Telomeric Double Strand Breaks in G1 Human Cells Facilitate Formation of 5′ C-Rich Overhangs and Recruitment of TERRA

Telomeric Double Strand Breaks in G1 Human Cells Facilitate Formation of 5′ C-Rich Overhangs and Recruitment of TERRA

Telomeres, repetitive nucleoprotein complexes that protect chromosomal termini and prevent them from activating inappropriate DNA damage responses (DDRs), shorten with cell division and thus with aging. Here, we characterized the human cellular response to targeted telomeric double-strand breaks (DS...

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Bibliographic Details
Main Authors: Christopher B. Nelson, Taghreed M. Alturki, Jared J. Luxton, Lynn E. Taylor, David G. Maranon, Keiko Muraki, John P. Murnane, Susan M. Bailey
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Genetics
Subjects:
telomeres
telomere double-strand breaks(DSBs)
telomeric C-rich overhangs
telomere repeat-containing RNA (TERRA)
alternative lengthening of telomeres (ALT)
G1 human cells
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.644803/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.644803/full

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