Primary hepatocytes isolated from human and porcine donors display similar patterns of cytochrome p450 expression following exposure to prototypical activators of AhR, CAR and PXR

Primary hepatocytes isolated from human and porcine donors display similar patterns of cytochrome p450 expression following exposure to prototypical activators of AhR, CAR and PXR

The hepatic cytochrome p450’s (CYP) are of major importance for the metabolism of xenobiotics and knowledge about their regulation is crucial. This knowledge often originates from cell models; primary human hepatocytes (PHH) being the gold standard. However, due to limited availability of high-quali...

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Bibliographic Details
Main Authors: Sabine Gerbal-Chaloin, Philippe Briolotti, Martine Daujat-Chavanieu, Martin Krøyer Rasmussen
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Current Research in Toxicology
Subjects:
Liver cells
Detoxification
Pig
Model
Gene-expression
RT-PCR
Online Access:http://www.sciencedirect.com/science/article/pii/S2666027X21000153

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http://www.sciencedirect.com/science/article/pii/S2666027X21000153

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