Transport Oligonucleotides–a Novel System for Intracellular Delivery Of Antisense Therapeutics

Transport Oligonucleotides–a Novel System for Intracellular Delivery Of Antisense Therapeutics

Biological activity of antisense oligonucleotides (asON), especially those with a neutral backbone, is often attenuated by poor cellular accumulation. In the present proof-of-concept study, we propose a novel delivery system for asONs which implies the delivery of modified antisense oligonucleotides...

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Bibliographic Details
Main Authors: Oleg V. Markov, Anton V. Filatov, Maxim S. Kupryushkin, Ivan V. Chernikov, Olga A. Patutina, Anton A. Strunov, Elena L. Chernolovskaya, Valentin V. Vlassov, Dmitrii V. Pyshnyi, Marina A. Zenkova
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Molecules
Subjects:
antisense oligonucleotide
lipophilic oligonucleotide conjugates
delivery
transport oligonucleotide
multiple drug resistance
Online Access:https://www.mdpi.com/1420-3049/25/16/3663

Internet

https://www.mdpi.com/1420-3049/25/16/3663

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