Cellular dosimetry of [177Lu]Lu-DOTA-[Tyr3]octreotate radionuclide therapy: the impact of modeling assumptions on the correlation with in vitro cytotoxicity

Cellular dosimetry of [177Lu]Lu-DOTA-[Tyr3]octreotate radionuclide therapy: the impact of modeling assumptions on the correlation with in vitro cytotoxicity

Abstract Background Survival and linear-quadratic model fitting parameters implemented in treatment planning for targeted radionuclide therapy depend on accurate cellular dosimetry. Therefore, we have built a refined cellular dosimetry model for [177Lu]Lu-DOTA-[Tyr3]octreotate (177Lu-DOTATATE) in vi...

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Bibliographic Details
Main Authors: Giulia Tamborino, Marijke De Saint-Hubert, Lara Struelens, Dayana C. Seoane, Eline A. M. Ruigrok, An Aerts, Wiggert A. van Cappellen, Marion de Jong, Mark W. Konijnenberg, Julie Nonnekens
Format: Article
Language:English
Published: SpringerOpen 2020-02-01
Series:EJNMMI Physics
Subjects:
Cellular dosimetry
[177Lu]Lu-DOTA-[Tyr3]octreotate
Polygonal mesh
S values
in vitro cytotoxicity correlation
Online Access:https://doi.org/10.1186/s40658-020-0276-5

Internet

https://doi.org/10.1186/s40658-020-0276-5

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