Conformation and Domain Movement Analysis of Human Matrix Metalloproteinase-2: Role of Associated Zn<sup>2+</sup> and Ca<sup>2+</sup> Ions

Conformation and Domain Movement Analysis of Human Matrix Metalloproteinase-2: Role of Associated Zn<sup>2+</sup> and Ca<sup>2+</sup> Ions

Matrix metaloproteinase-2 (MMP-2) is an extracellular Zn<sup>2+</sup> protease specific to type I and IV collagens. Its expression is associated with several inflammatory, degenerative, and malignant diseases. Conformational properties, domain movements, and interactions between MMP-2 an...

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Bibliographic Details
Main Authors: Leah Voit-Ostricki, Sándor Lovas, Charles R. Watts
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
molecular dynamics
matrix metalloproteinase
domain movement
zinc binding protein
calcium binding protein
Online Access:https://www.mdpi.com/1422-0067/20/17/4194

Internet

https://www.mdpi.com/1422-0067/20/17/4194

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