miRNA and mRNA Profiling Links Connexin Deficiency to Deafness via Early Oxidative Damage in the Mouse Stria Vascularis

miRNA and mRNA Profiling Links Connexin Deficiency to Deafness via Early Oxidative Damage in the Mouse Stria Vascularis

Pathogenic mutations in the non-syndromic hearing loss and deafness 1 (DFNB1) locus are the primary cause of monogenic inheritance for prelingual hearing loss. To unravel molecular pathways involved in etiopathology and look for early degeneration biomarkers, we used a system biology approach to ana...

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Bibliographic Details
Main Authors: Giulia Gentile, Fabiola Paciello, Veronica Zorzi, Antonio Gianmaria Spampinato, Maria Guarnaccia, Giulia Crispino, Abraham Tettey-Matey, Ferdinando Scavizzi, Marcello Raspa, Anna Rita Fetoni, Sebastiano Cavallaro, Fabio Mammano
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
connexins
molecular pathway analysis
early degeneration
systems biology
hearing loss
vascular dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.616878/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.616878/full

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