An in vitro model of antibody-enhanced killing of the intracellular parasite Leishmania amazonensis.

Footpad infection of C3HeB/FeJ mice with Leishmania amazonensis leads to chronic lesions accompanied by large parasite loads. Co-infecting these animals with L. major leads to induction of an effective Th1 immune response that can resolve these lesions. This cross-protection can be recapitulated in...

Full description

Bibliographic Details
Main Authors: Katherine N Gibson-Corley, Marie M Bockenstedt, Huijuan Li, Paola M Boggiatto, Yashdeep Phanse, Christine A Petersen, Bryan H Bellaire, Douglas E Jones
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4156363?pdf=render