Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APPswe/PS1dE9 transgenic mice: Effect of long-term treatment with paroxetine

Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APPswe/PS1dE9 transgenic mice: Effect of long-term treatment with paroxetine

Altered neurogenesis may influence hippocampal functions such as learning and memory in Alzheimer's disease. Selective serotonin reuptake inhibitors enhance neurogenesis and have been reported to reduce cerebral amyloidosis in both humans and transgenic mice. We have used stereology to assess t...

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Bibliographic Details
Main Authors: Louise Ørum Olesen, Mithula Sivasaravanaparan, Maurizio Severino, Alicia A. Babcock, Elena V. Bouzinova, Mark J. West, Ove Wiborg, Bente Finsen
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Neurobiology of Disease
Subjects:
Neurogenesis
Hippocampus
APP/PS1 mice
SSRI
Paroxetine
Spontaneous alternation behaviour
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117301031

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http://www.sciencedirect.com/science/article/pii/S0969996117301031

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