Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota
Summary: In rodents, lower brown adipose tissue (BAT) activity is associated with greater liver steatosis and changes in the gut microbiome. However, little is known about these relationships in humans. In adults (n = 60), we assessed hepatic fat and cold-stimulated BAT activity using magnetic reson...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | Cell Reports Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266637912100255X |
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doaj-3f605dad37834d20b7e3330887e81098 |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Basma A. Ahmed Frank J. Ong Nicole G. Barra Denis P. Blondin Elizabeth Gunn Stephan M. Oreskovich Jake C. Szamosi Saad A. Syed Emily K. Hutchings Norman B. Konyer Nina P. Singh Julian M. Yabut Eric M. Desjardins Fernando F. Anhê Kevin P. Foley Alison C. Holloway Michael D. Noseworthy Francois Haman Andre C. Carpentier Michael G. Surette Jonathan D. Schertzer Zubin Punthakee Gregory R. Steinberg Katherine M. Morrison |
| spellingShingle |
Basma A. Ahmed Frank J. Ong Nicole G. Barra Denis P. Blondin Elizabeth Gunn Stephan M. Oreskovich Jake C. Szamosi Saad A. Syed Emily K. Hutchings Norman B. Konyer Nina P. Singh Julian M. Yabut Eric M. Desjardins Fernando F. Anhê Kevin P. Foley Alison C. Holloway Michael D. Noseworthy Francois Haman Andre C. Carpentier Michael G. Surette Jonathan D. Schertzer Zubin Punthakee Gregory R. Steinberg Katherine M. Morrison Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota Cell Reports Medicine non-alcoholic fatty liver disease hepatic fat brown adipose tissue magnetic resonance imaging proton density fat fraction microbiota |
| author_facet |
Basma A. Ahmed Frank J. Ong Nicole G. Barra Denis P. Blondin Elizabeth Gunn Stephan M. Oreskovich Jake C. Szamosi Saad A. Syed Emily K. Hutchings Norman B. Konyer Nina P. Singh Julian M. Yabut Eric M. Desjardins Fernando F. Anhê Kevin P. Foley Alison C. Holloway Michael D. Noseworthy Francois Haman Andre C. Carpentier Michael G. Surette Jonathan D. Schertzer Zubin Punthakee Gregory R. Steinberg Katherine M. Morrison |
| author_sort |
Basma A. Ahmed |
| title |
Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota |
| title_short |
Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota |
| title_full |
Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota |
| title_fullStr |
Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota |
| title_full_unstemmed |
Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota |
| title_sort |
lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota |
| publisher |
Elsevier |
| series |
Cell Reports Medicine |
| issn |
2666-3791 |
| publishDate |
2021-09-01 |
| description |
Summary: In rodents, lower brown adipose tissue (BAT) activity is associated with greater liver steatosis and changes in the gut microbiome. However, little is known about these relationships in humans. In adults (n = 60), we assessed hepatic fat and cold-stimulated BAT activity using magnetic resonance imaging and the gut microbiota with 16S sequencing. We transplanted gnotobiotic mice with feces from humans to assess the transferability of BAT activity through the microbiota. Individuals with NAFLD (n = 29) have lower BAT activity than those without, and BAT activity is inversely related to hepatic fat content. BAT activity is not related to the characteristics of the fecal microbiota and is not transmissible through fecal transplantation to mice. Thus, low BAT activity is associated with higher hepatic fat accumulation in human adults, but this does not appear to have been mediated through the gut microbiota. |
| topic |
non-alcoholic fatty liver disease hepatic fat brown adipose tissue magnetic resonance imaging proton density fat fraction microbiota |
| url |
http://www.sciencedirect.com/science/article/pii/S266637912100255X |
| work_keys_str_mv |
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doaj-3f605dad37834d20b7e3330887e810982021-09-25T05:11:42ZengElsevierCell Reports Medicine2666-37912021-09-0129100397Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiotaBasma A. Ahmed0Frank J. Ong1Nicole G. Barra2Denis P. Blondin3Elizabeth Gunn4Stephan M. Oreskovich5Jake C. Szamosi6Saad A. Syed7Emily K. Hutchings8Norman B. Konyer9Nina P. Singh10Julian M. Yabut11Eric M. Desjardins12Fernando F. Anhê13Kevin P. Foley14Alison C. Holloway15Michael D. Noseworthy16Francois Haman17Andre C. Carpentier18Michael G. Surette19Jonathan D. Schertzer20Zubin Punthakee21Gregory R. Steinberg22Katherine M. Morrison23Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, CanadaCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada; Department of Pediatrics, McMaster University, Hamilton, ON L8S 4L8, CanadaCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4L8, CanadaFaculty of Medicine and Health Sciences, Department of Medicine, Division of Neurology, Centre de recherche du CHUS, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, CanadaCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada; Department of Pediatrics, McMaster University, Hamilton, ON L8S 4L8, CanadaCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada; Department of Pediatrics, McMaster University, Hamilton, ON L8S 4L8, CanadaFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4L8, Canada; Farncombe Metagenomics Facility, Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, CanadaDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, CanadaCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada; Department of Pediatrics, McMaster University, Hamilton, ON L8S 4L8, CanadaImaging Research Centre, St. Joseph’s Healthcare, Hamilton, ON L8N 4A6, CanadaDepartment of Radiology, McMaster University, Hamilton, ON L8S 4L8, CanadaCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, CanadaCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, CanadaCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4L8, CanadaCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4L8, CanadaCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada; Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON L8S 4L8, CanadaCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada; Imaging Research Centre, St. Joseph’s Healthcare, Hamilton, ON L8N 4A6, Canada; Department of Radiology, McMaster University, Hamilton, ON L8S 4L8, Canada; Department of Electrical and Computer Engineering, McMaster University, Hamilton, ON L8S 4L8, Canada; School of Biomedical Engineering, McMaster University, Hamilton, ON L8S 4L8, CanadaFaculty of Health Sciences, University of Ottawa, Ottawa, ON K1N 6N5, CanadaDivision of Endocrinology, Department of Medicine, Centre de recherche du CHUS, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, CanadaCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4L8, Canada; Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, CanadaCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4L8, CanadaCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada; Department of Pediatrics, McMaster University, Hamilton, ON L8S 4L8, Canada; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, CanadaCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada; Corresponding authorCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada; Department of Pediatrics, McMaster University, Hamilton, ON L8S 4L8, Canada; Corresponding authorSummary: In rodents, lower brown adipose tissue (BAT) activity is associated with greater liver steatosis and changes in the gut microbiome. However, little is known about these relationships in humans. In adults (n = 60), we assessed hepatic fat and cold-stimulated BAT activity using magnetic resonance imaging and the gut microbiota with 16S sequencing. We transplanted gnotobiotic mice with feces from humans to assess the transferability of BAT activity through the microbiota. Individuals with NAFLD (n = 29) have lower BAT activity than those without, and BAT activity is inversely related to hepatic fat content. BAT activity is not related to the characteristics of the fecal microbiota and is not transmissible through fecal transplantation to mice. Thus, low BAT activity is associated with higher hepatic fat accumulation in human adults, but this does not appear to have been mediated through the gut microbiota.http://www.sciencedirect.com/science/article/pii/S266637912100255Xnon-alcoholic fatty liver diseasehepatic fatbrown adipose tissuemagnetic resonance imagingproton density fat fractionmicrobiota |