Are SIRT1 activators another indirect method to increase AMPK for beneficial effects on aging and the metabolic syndrome?

by Rebecca J. Ford, Eric M. Desjardins, Gregory R. Steinberg
Published 2017-05-01

AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis

by Sandra Galic, Kim Loh, Lisa Murray-Segal, Gregory R Steinberg, Zane B Andrews, Bruce E Kemp
Published 2018-02-01

High intensity interval training improves liver and adipose tissue insulin sensitivity

by Katarina Marcinko, Sarah R. Sikkema, M. Constantine Samaan, Bruce E. Kemp, Morgan D. Fullerton, Gregory R. Steinberg
Published 2015-12-01

Elevated mitochondrial oxidative stress impairs metabolic adaptations to exercise in skeletal muscle.

by Justin D Crane, Arkan Abadi, Bart P Hettinga, Daniel I Ogborn, Lauren G MacNeil, Gregory R Steinberg, Mark A Tarnopolsky
Published 2013-01-01

Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney diseaseResearch in context

by Wouter N. Leonhard, Xuewen Song, Anish A. Kanhai, Ioan-Andrei Iliuta, Andrea Bozovic, Gregory R. Steinberg, Dorien J.M. Peters, York Pei
Published 2019-09-01

Enhanced lipid oxidation and maintenance of muscle insulin sensitivity despite glucose intolerance in a diet-induced obesity mouse model.

by Karin E Trajcevski, Hayley M O'Neill, David C Wang, Melissa M Thomas, Dhuha Al-Sajee, Gregory R Steinberg, Rolando B Ceddia, Thomas J Hawke
Published 2013-01-01

The diabetes medication Canagliflozin reduces cancer cell proliferation by inhibiting mitochondrial complex-I supported respiration

by Linda A. Villani, Brennan K. Smith, Katarina Marcinko, Rebecca J. Ford, Lindsay A. Broadfield, Alex E. Green, Vanessa P. Houde, Paola Muti, Theodoros Tsakiridis, Gregory R. Steinberg
Published 2016-10-01

Markers of skeletal muscle mitochondrial function and lipid accumulation are moderately associated with the homeostasis model assessment index of insulin resistance in obese men.

by Imtiaz A Samjoo, Adeel Safdar, Adeel Safdar, Mazen J Hamadeh, Alexander W Glover, Nicholas J Mocellin, Jose Santana, Jonathan P Little, Gregory R Steinberg, Sandeep Raha, Mark A Tarnopolsky
Published 2013-01-01

PPARδ activation attenuates hepatic steatosis in Ldlr−/− mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity

by Lazar A. Bojic, Dawn E. Telford, Morgan D. Fullerton, Rebecca J. Ford, Brian G. Sutherland, Jane Y. Edwards, Cynthia G. Sawyez, Robert Gros, Bruce E. Kemp, Gregory R. Steinberg, Murray W. Huff
Published 2014-07-01

The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK[S]

by Nadya M. Morrow, Amy C. Burke, Joshua P. Samsoondar, Kyle E. Seigel, Andrew Wang, Dawn E. Telford, Brian G. Sutherland, Conor O'Dwyer, Gregory R. Steinberg, Morgan D. Fullerton, Murray W. Huff
Published 2020-03-01

Effects of Estrogens on Adipokines and Glucose Homeostasis in Female Aromatase Knockout Mice.

by Michelle L Van Sinderen, Gregory R Steinberg, Sebastian B Jørgensen, Jane Honeyman, Jenny D Chow, Kerrie A Herridge, Amy L Winship, Evdokia Dimitriadis, Margaret E E Jones, Evan R Simpson, Wah Chin Boon
Published 2015-01-01

FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasi...

by Emilio P. Mottillo, Eric M. Desjardins, Andreas M. Fritzen, Vito Z. Zou, Justin D. Crane, Julian M. Yabut, Bente Kiens, Derek M. Erion, Adhiraj Lanba, James G. Granneman, Saswata Talukdar, Gregory R. Steinberg
Published 2017-06-01

The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice

by Katarina Marcinko, Adam L. Bujak, James S.V. Lally, Rebecca J. Ford, Tammy H. Wong, Brennan K. Smith, Bruce E. Kemp, Yonchu Jenkins, Wei Li, Todd M. Kinsella, Yasumichi Hitoshi, Gregory R. Steinberg
Published 2015-09-01

Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance

by Julian M. Yabut, Eric M. Desjardins, Eric J. Chan, Emily A. Day, Julie M. Leroux, Bo Wang, Elizabeth D. Crane, Wesley Wong, Katherine M. Morrison, Justin D. Crane, Waliul I. Khan, Gregory R. Steinberg
Published 2020-01-01

Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

by Stephen L. Pinkosky, Roger S. Newton, Emily A. Day, Rebecca J. Ford, Sarka Lhotak, Richard C. Austin, Carolyn M. Birch, Brennan K. Smith, Sergey Filippov, Pieter H.E. Groot, Gregory R. Steinberg, Narendra D. Lalwani
Published 2016-11-01

Combined metformin-salicylate treatment provides improved anti-tumor activity and enhanced radiotherapy response in prostate cancer; drug synergy at clinically relevant doses

by Evangelia E. Tsakiridis, Lindsay Broadfield, Katarina Marcinko, Olga-Demetra Biziotis, Amr Ali, Bassem Mekhaeil, Elham Ahmadi, Kanwaldeep Singh, Aruz Mesci, Panayiotis G. Zacharidis, Alexander E. Anagnostopoulos, Tobias Berg, Paola Muti, Gregory R. Steinberg, Theodoros Tsakiridis
Published 2021-11-01

Hepatic glucose intolerance precedes hepatic steatosis in the male aromatase knockout (ArKO) mouse.

by Michelle L Van Sinderen, Gregory R Steinberg, Sebastian B Jørgensen, Sarah Q To, Kevin C Knower, Colin D Clyne, Jane Honeyman, Jenny D Chow, Kerrie A Herridge, Margaret E E Jones, Evan R Simpson, Wah Chin Boon
Published 2014-01-01

Salsalate reduces atherosclerosis through AMPKβ1 in mice

by Emily A. Day, Rebecca J. Ford, Brennan K. Smith, Vanessa P. Houde, Stephanie Stypa, Sonia Rehal, Sarka Lhotak, Bruce E. Kemp, Bernardo L. Trigatti, Geoff H. Werstuck, Richard C. Austin, Morgan D. Fullerton, Gregory R. Steinberg
Published 2021-11-01

Salicylate improves macrophage cholesterol homeostasis via activation of Ampk

by Morgan D. Fullerton, Rebecca J. Ford, Chelsea P. McGregor, Nicholas D. LeBlond, Shayne A. Snider, Stephanie A. Stypa, Emily A. Day, Šárka Lhoták, Jonathan D. Schertzer, Richard C. Austin, Bruce E. Kemp, Gregory R. Steinberg
Published 2015-05-01

Interleukin-15 modulates adipose tissue by altering mitochondrial mass and activity.

by Nicole G Barra, Rengasamy Palanivel, Emmanuel Denou, Marianne V Chew, Amy Gillgrass, Tina D Walker, Josh Kong, Carl D Richards, Manel Jordana, Stephen M Collins, Bernardo L Trigatti, Alison C Holloway, Sandeep Raha, Gregory R Steinberg, Ali A Ashkar
Published 2014-01-01