GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injury

by Khrystyna Platko, Paul F. Lebeau, Jae Hyun Byun, Samantha V. Poon, Emily A. Day, Melissa E. MacDonald, Nicholas Holzapfel, Aurora Mejia-Benitez, Kenneth N. Maclean, Joan C. Krepinsky, Richard C. Austin
Published 2019-09-01

Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance

by Julian M. Yabut, Eric M. Desjardins, Eric J. Chan, Emily A. Day, Julie M. Leroux, Bo Wang, Elizabeth D. Crane, Wesley Wong, Katherine M. Morrison, Justin D. Crane, Waliul I. Khan, Gregory R. Steinberg
Published 2020-01-01

Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

by Stephen L. Pinkosky, Roger S. Newton, Emily A. Day, Rebecca J. Ford, Sarka Lhotak, Richard C. Austin, Carolyn M. Birch, Brennan K. Smith, Sergey Filippov, Pieter H.E. Groot, Gregory R. Steinberg, Narendra D. Lalwani
Published 2016-11-01

Salsalate reduces atherosclerosis through AMPKβ1 in mice

by Emily A. Day, Rebecca J. Ford, Brennan K. Smith, Vanessa P. Houde, Stephanie Stypa, Sonia Rehal, Sarka Lhotak, Bruce E. Kemp, Bernardo L. Trigatti, Geoff H. Werstuck, Richard C. Austin, Morgan D. Fullerton, Gregory R. Steinberg
Published 2021-11-01

Salicylate improves macrophage cholesterol homeostasis via activation of Ampk

by Morgan D. Fullerton, Rebecca J. Ford, Chelsea P. McGregor, Nicholas D. LeBlond, Shayne A. Snider, Stephanie A. Stypa, Emily A. Day, Šárka Lhoták, Jonathan D. Schertzer, Richard C. Austin, Bruce E. Kemp, Gregory R. Steinberg
Published 2015-05-01

The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue

by Bo Wang, Evangelia E. Tsakiridis, Shuman Zhang, Andrea Llanos, Eric M. Desjardins, Julian M. Yabut, Alexander E. Green, Emily A. Day, Brennan K. Smith, James S. V. Lally, Jianhan Wu, Amogelang R. Raphenya, Krishna A. Srinivasan, Andrew G. McArthur, Shingo Kajimura, Jagdish Suresh Patel, Michael G. Wade, Katherine M. Morrison, Alison C. Holloway, Gregory R. Steinberg
Published 2021-08-01

Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models

by Ryan M. Esquejo, Christopher T. Salatto, Jake Delmore, Bina Albuquerque, Allan Reyes, Yuji Shi, Rob Moccia, Emily Cokorinos, Matthew Peloquin, Mara Monetti, Jason Barricklow, Eliza Bollinger, Brennan K. Smith, Emily A. Day, Chuong Nguyen, Kieran F. Geoghegan, John M. Kreeger, Alan Opsahl, Jessica Ward, Amit S. Kalgutkar, David Tess, Lynne Butler, Norimitsu Shirai, Timothy F. Osborne, Gregory R. Steinberg, Morris J. Birnbaum, Kimberly O. Cameron, Russell A. Miller
Published 2018-05-01