PEP-1-GLRX1 Reduces Dopaminergic Neuronal Cell Loss by Modulating MAPK and Apoptosis Signaling in Parkinson’s Disease

PEP-1-GLRX1 Reduces Dopaminergic Neuronal Cell Loss by Modulating MAPK and Apoptosis Signaling in Parkinson’s Disease

Parkinson’s disease (PD) is characterized mainly by the loss of dopaminergic neurons in the substantia nigra (SN) mediated via oxidative stress. Although glutaredoxin-1 (GLRX1) is known as one of the antioxidants involved in cell survival, the effects of GLRX1 on PD are still unclear. In this study,...

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Bibliographic Details
Main Authors: Yeon Joo Choi, Dae Won Kim, Min Jea Shin, Hyeon Ji Yeo, Eun Ji Yeo, Lee Re Lee, Yejin Song, Duk-Soo Kim, Kyu Hyung Han, Jinseu Park, Keun Wook Lee, Jong Kook Park, Won Sik Eum, Soo Young Choi
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
Parkinson’s disease
PEP-1-GLRX1
oxidative stress
MAPK signaling
neuroprotection
protein therapy
Online Access:https://www.mdpi.com/1420-3049/26/11/3329

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https://www.mdpi.com/1420-3049/26/11/3329

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