Curcumin Derivative Cur20 Attenuated Cerebral Ischemic Injury by Antioxidant Effect and HIF-1α/VEGF/TFEB-Activated Angiogenesis

Curcumin Derivative Cur20 Attenuated Cerebral Ischemic Injury by Antioxidant Effect and HIF-1α/VEGF/TFEB-Activated Angiogenesis

In this paper, a curcumin derivative Cur20 was synthesized for better hydrolytic stability, which showed a higher angiogenic effect on zebrafish model than curcumin. In order to reveal the potential effects on neuroprotection, a mouse model of vascular dementia (VaD) induced by permanent right commo...

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Bibliographic Details
Main Authors: Runfang Zhang, Tingkui Zhao, Beibei Zheng, Yun Zhang, Xiaohui Li, Feng Zhang, Juan Cen, Shaofeng Duan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
curcumin derivative
vascular dementia
brain microvessel endothelial cells
angiogenesis
zebrafish
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.648107/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.648107/full

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