IL-7 up-regulates TNF-alpha-dependent osteoclastogenesis in patients affected by solid tumor.

IL-7 up-regulates TNF-alpha-dependent osteoclastogenesis in patients affected by solid tumor.

BACKGROUND: Interleukin-7 (IL-7) is a potent regulator of lymphocyte development, which has also significant effects on bone; in fact it is a potent osteoclastogenic factor. Some human solid tumors produce high IL-7 levels, suggesting a potential IL-7 role on tumor development and progression. METHO...

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Main Authors: Ilaria Roato, Giacomina Brunetti, Eva Gorassini, Maria Grano, Silvia Colucci, Lisa Bonello, Lucio Buffoni, Roberto Manfredi, Enrico Ruffini, Davide Ottaviani, Libero Ciuffreda, Antonio Mussa, Riccardo Ferracini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1762428?pdf=render

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http://europepmc.org/articles/PMC1762428?pdf=render

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