N-alkylated aminoacyl sulfamoyladenosines as potential inhibitors of aminoacylation reactions and microcin C analogues containing D-amino acids.

N-alkylated aminoacyl sulfamoyladenosines as potential inhibitors of aminoacylation reactions and microcin C analogues containing D-amino acids.

Microcin C analogues were recently envisaged as important compounds for the development of novel antibiotics. Two issues that may pose problems to these potential antibiotics are possible acquisition of resistance through acetylation and in vivo instability of the peptide chain. N-methylated aminoac...

Full description

Bibliographic Details
Main Authors: Gaston H Vondenhoff, Ksenia Pugach, Bharat Gadakh, Laurence Carlier, Jef Rozenski, Mathy Froeyen, Konstantin Severinov, Arthur Van Aerschot
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3817062?pdf=render

Internet

http://europepmc.org/articles/PMC3817062?pdf=render

Similar Items