VAS2870 Inhibits Histamine-Induced Calcium Signaling and vWF Secretion in Human Umbilical Vein Endothelial Cells

VAS2870 Inhibits Histamine-Induced Calcium Signaling and vWF Secretion in Human Umbilical Vein Endothelial Cells

In this study, we investigated the effects of NAD(P)H oxidase (NOX) inhibitor VAS2870 (3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine) on the histamine-induced elevation of free cytoplasmic calcium concentration ([Ca<sup>2+</sup>]<sub>i</sub>) and the secreti...

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Bibliographic Details
Main Authors: Pavel V. Avdonin, Elena Yu. Rybakova, Piotr P. Avdonin, Sergei K. Trufanov, Galina Yu. Mironova, Alexandra A. Tsitrina, Nikolay V. Goncharov
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Cells
Subjects:
histamine
calcium
endothelial cells
NADPH-oxidase
VAS2870
von Willebrand factor
aorta
relaxation
Online Access:https://www.mdpi.com/2073-4409/8/2/196

Internet

https://www.mdpi.com/2073-4409/8/2/196

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