Intrinsically Disordered Linkers Impart Processivity on Enzymes by Spatial Confinement of Binding Domains

Intrinsically Disordered Linkers Impart Processivity on Enzymes by Spatial Confinement of Binding Domains

(1) Background: Processivity is common among enzymes and mechanochemical motors that synthesize, degrade, modify or move along polymeric substrates, such as DNA, RNA, polysaccharides or proteins. Processive enzymes can make multiple rounds of modification without releasing the substrate/partner, mak...

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Bibliographic Details
Main Authors: Beata Szabo, Tamas Horvath, Eva Schad, Nikoletta Murvai, Agnes Tantos, Lajos Kalmar, Lucía Beatriz Chemes, Kyou-Hoon Han, Peter Tompa
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
enzyme efficiency
polymeric substrate
processive enzyme
disordered linker
binding motif
binding domain
spatial search
local effective concentration
Online Access:https://www.mdpi.com/1422-0067/20/9/2119

Internet

https://www.mdpi.com/1422-0067/20/9/2119

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