Enhancer-Mediated Oncogenic Function of the Menin Tumor Suppressor in Breast Cancer

Enhancer-Mediated Oncogenic Function of the Menin Tumor Suppressor in Breast Cancer

While the multiple endocrine neoplasia type 1 (MEN1) gene functions as a tumor suppressor in a variety of cancer types, we explored its oncogenic role in breast tumorigenesis. The MEN1 gene product menin is involved in H3K4 trimethylation and co-activates transcription. We integrated ChIP-seq and RN...

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Bibliographic Details
Main Authors: Koen M.A. Dreijerink, Anna C. Groner, Erica S.M. Vos, Alba Font-Tello, Lei Gu, David Chi, Jaime Reyes, Jennifer Cook, Elgene Lim, Charles Y. Lin, Wouter de Laat, Prakash K. Rao, Henry W. Long, Myles Brown
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
breast cancer
MEN1
tumor suppressor
oncogene
transcription
epigenetics
menin
histone H3K4 trimethylation
enhancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717302061

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http://www.sciencedirect.com/science/article/pii/S2211124717302061

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