Novel fatty acyl apoE mimetic peptides have increased potency to reduce plasma cholesterol in mice and macaques[S]

Novel fatty acyl apoE mimetic peptides have increased potency to reduce plasma cholesterol in mice and macaques[S]

Ac-hE18A-NH2 is a dual-domain apoE mimetic peptide that possesses the putative receptor binding domain from apoE (LRKLRKRLLR, denoted hE; residues 141–150) covalently attached to lipid-associating peptide 18A. Like apoE, Ac-hE18A-NH2 reduces plasma cholesterol in animal models and exhibits anti-infl...

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Bibliographic Details
Main Authors: G.M. Anantharamaiah, David W. Garber, Dennis Goldberg, Eric Morrel, Geeta Datta, Mayakonda N. Palgunachari, Thomas C. Register, Susan E. Appt, C. Roger White
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Journal of Lipid Research
Subjects:
peptides
low density lipoprotein
dyslipidemia
lipoproteins
apolipoprotein E
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520309081

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520309081

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