Epigenome‐wide analyses identify DNA methylation signatures of dementia risk

Epigenome‐wide analyses identify DNA methylation signatures of dementia risk

Abstract Introduction Dementia pathogenesis begins years before clinical symptom onset, necessitating the understanding of premorbid risk mechanisms. Here we investigated potential pathogenic mechanisms by assessing DNA methylation associations with dementia risk factors in Alzheimer's disease...

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Bibliographic Details
Main Authors: Rosie M. Walker, Mairead L. Bermingham, Kadi Vaher, Stewart W. Morris, Toni‐Kim Clarke, Andrew D. Bretherick, Yanni Zeng, Carmen Amador, Konrad Rawlik, Kalyani Pandya, Caroline Hayward, Archie Campbell, David J. Porteous, Andrew M. McIntosh, Riccardo E. Marioni, Kathryn L. Evans
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Subjects:
alcohol
Alzheimer's disease
dementia
DNA methylation
genetic risk score
risk factors
Online Access:https://doi.org/10.1002/dad2.12078

Internet

https://doi.org/10.1002/dad2.12078

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