Tau reduction diminishes spatial learning and memory deficits after mild repetitive traumatic brain injury in mice.

Because reduction of the microtubule-associated protein Tau has beneficial effects in mouse models of Alzheimer's disease and epilepsy, we wanted to determine whether this strategy can also improve the outcome of mild traumatic brain injury (TBI).We adapted a mild frontal impact model of TBI fo...

Full description

Bibliographic Details
Main Authors: Jason S Cheng, Ryan Craft, Gui-Qiu Yu, Kaitlyn Ho, Xin Wang, Geetha Mohan, Sergey Mangnitsky, Ravikumar Ponnusamy, Lennart Mucke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4281043?pdf=render