Anthrax toxin translocation complex reveals insight into the lethal factor unfolding and refolding mechanism

Abstract Translocation is essential to the anthrax toxin mechanism. Protective antigen (PA), the binding component of this AB toxin, forms an oligomeric pore that translocates lethal factor (LF) or edema factor, the active components of the toxin, into the cell. Structural details of the translocati...

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Bibliographic Details
Main Authors: Alexandra J. Machen, Mark T. Fisher, Bret D. Freudenthal
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-91596-3