Multimodal Treatment Eliminates Cancer Stem Cells and Leads to Long-Term Survival in Primary Human Pancreatic Cancer Tissue Xenografts.

In spite of intense research efforts, pancreatic ductal adenocarcinoma remains one of the most deadly malignancies in the world. We and others have previously identified a subpopulation of pancreatic cancer stem cells within the tumor as a critical therapeutic target and additionally shown that the...

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Main Authors: Patrick C Hermann, Sara M Trabulo, Bruno Sainz, Anamaria Balic, Elena Garcia, Stephan A Hahn, Mallaredy Vandana, Sanjeeb K Sahoo, Patrizia Tunici, Annette Bakker, Manuel Hidalgo, Christopher Heeschen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3688976?pdf=render