Ligand pathways in neuroglobin revealed by low-temperature photodissociation and docking experiments

Ligand pathways in neuroglobin revealed by low-temperature photodissociation and docking experiments

A combined biophysical approach was applied to map gas-docking sites within murine neuroglobin (Ngb), revealing snapshots of events that might govern activity and dynamics in this unique hexacoordinate globin, which is most likely to be involved in gas-sensing in the central nervous system and for w...

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Bibliographic Details
Main Authors: Chiara Ardiccioni, Alessandro Arcovito, Stefano Della Longa, Peter van der Linden, Dominique Bourgeois, Martin Weik, Linda Celeste Montemiglio, Carmelinda Savino, Giovanna Avella, Cécile Exertier, Philippe Carpentier, Thierry Prangé, Maurizio Brunori, Nathalie Colloc'h, Beatrice Vallone
Format: Article
Language:English
Published: International Union of Crystallography 2019-09-01
Series:IUCrJ
Subjects:
ultralow-temperature X-ray crystallography
XANES
heme protein
neuroglobin
oxygen binding
cryo-trapping
crystal microspectroscopy
neuroprotection
structural biology
CO photolysis
soak-and-freeze pressurization
structure determination
protein structure
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2052252519008157

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http://scripts.iucr.org/cgi-bin/paper?S2052252519008157

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