Tubuloglomerular Feedback in Renal Glucosuria: Mimicking Long-term SGLT-2 Inhibitor Therapy

A patient with renal glucosuria due to a congenital knock-out of the sodium-glucose cotransporter 2 (SGLT-2) protein because of a compound heterozygous mutation in the SLC5A2 gene may provide a natural model mimicking the effects of long-term SGLT-2 inhibitor therapy, which has been shown to exert k...

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Bibliographic Details
Main Authors: Hannes Neuwirt, Andrea Burtscher, David Cherney, Gert Mayer, Christoph Ebenbichler
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Kidney Medicine
Online Access:http://www.sciencedirect.com/science/article/pii/S259005951930175X