Antitumor Effects In Vitro and In Vivo and Mechanisms of Protection against Melanoma B16F10-Nex2 Cells By Fastuosain, a Cysteine Proteinase from Bromelia fastuosa

Antitumor Effects In Vitro and In Vivo and Mechanisms of Protection against Melanoma B16F10-Nex2 Cells By Fastuosain, a Cysteine Proteinase from Bromelia fastuosa

In the present work, the antitumor effect of fastuosain, a cysteine proteinase from Bromelia fastuosa, was investigated. In the intravenous model of lung colonization in C57BI/6 mice, fastuosain and bromelain injected intraperitoneally were protective, very few nodules of B16F10-Nex2 melanoma cells...

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Bibliographic Details
Main Authors: Carla A. Guimarães-Ferreira, Elaine G. Rodrigues, Renato A. Mortara, Hamilton Cabral, Fabiana A. Serrano, Ricardo Ribeiro-dos-Santos, Luiz R. Travassos
Format: Article
Language:English
Published: Elsevier 2007-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Fastuosain
bromelain
B16F10-Nex2 tumor cells
cathepsins B/L, protective antibodies
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607800327

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http://www.sciencedirect.com/science/article/pii/S1476558607800327

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